Allogeneic Marrow Engraftment Following Whole Body Irradiation in a Patient with Leukemia
نویسندگان
چکیده
منابع مشابه
Allogeneic marrow engraftment following whole body irradiation in a patient with leukemia. 1970.
T HE DEMONSTRATION OF A TRANSIENT MARROW GRAFT in a leukemic patient in 1956,’ and the treatment of victims of an irradiation accident in 1958,2 initiated a number of attempts to utilize allogeneic marrow grafts in patients with marrow failure or with leukemia. Recent reviews3’4 of those attempts show a notable lack of success with death due to failure of engraftment or to graft-vs-host disease...
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T HE SPONTANEOUS DEVELOPMENT of leukemia in a subhuman primate is an uncommon occurrence. Whereas ionizing radiation will predictably induce leukemia in certain strains of mice and rats and is associated with human leukemia, as far as we could ascertain, there are only two previously reported cases of leukemia associated with ionizing radiation in primates.1’2 The purpose of this report is to d...
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ESPITE RECENT improvements in posttransplant D immunosuppressive regimens, acute and chronic graftversus-host disease (GVHD) remain significant obstacles to successful marrow transplantation, particularly in patients not having an HLA-identical related donor. These findings have lead to continued interest in preventing GVHD by depleting T cells from the donor marrow. Initial animal experiments ...
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Murine bone marrow chimera models were used to assess the efficacy of host total body irradiation (TBI) given at different doses, dose rates, and fractionation schemes in providing for engraftment of syngeneic and allogeneic bone marrow. B6-Hbbd congenic and LP mice, respectively, were used as donors (10(7) bone marrow cells) for syngeneic and allogenic (H-2 compatible) transplantation in stand...
متن کاملA randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplantation Group.
Between October 1988 and December 1992, 167 patients with leukemia receiving marrow transplants from HLA-identical donors and conditioned with cyclophosphamide (120 mg/kg) were randomized to additional treatment with either busulfan (16 mg/kg, n = 88) or total body irradiation (TBI; n = 79). The busulfan-treated patients had an increased cumulative incidence of veno-occlusive disease of the liv...
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ژورنال
عنوان ژورنال: Blood
سال: 1970
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v35.6.741.741